Computational proteomics: management and analysis of proteomics data
نویسندگان
چکیده
منابع مشابه
Computational analysis of shotgun proteomics data.
Proteomics technology is progressing at an incredible rate. The latest generation of tandem mass spectrometers can now acquire tens of thousands of fragmentation spectra in a matter of hours. Furthermore, quantitative proteomics methods have been developed that incorporate a stable isotope-labeled internal standard for every peptide within a complex protein mixture for the measurement of relati...
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Data management is of growing importance in proteomics research. Therefore, this review first touches on the different types of proteomics methodologies along with their associated data types and underlying proteomics informatics. Next, we discuss the variety of different standardized file formats to exchange proteomics data as well as available public and local data management solutions to han...
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Proteomics enables understanding the composition, structure, function and interactions of the entire protein complement of a cell, a tissue, or an organism under exactly defined conditions. Some factors such as stress or drug effects will change the protein pattern and cause the present or absence of a protein or gradual variation in abundances. Changes in the proteome provide a snapshot of the...
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Mass Spectrometry (MS) based proteomics is becoming a powerful, widely used technique in order to identify different molecular targets in different pathological conditions [1]. Proteomics experiments involve different and heterogeneous technological platforms so a clear understanding of the function and errors related to each one has to be taken into account. In particular, data produced by mas...
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Genomics is the study of the genome, i.e. the whole hereditary information of an organism that is encoded in the DNA (or, for some viruses, RNA). Investigation of single genes, their functions and roles is becoming common practice in today's medical and biological research. Genome-wide sequencing projects have been completed for many organisms, including Homo Sapiens. Currently thousands of gen...
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ژورنال
عنوان ژورنال: Briefings in Bioinformatics
سال: 2007
ISSN: 1467-5463,1477-4054
DOI: 10.1093/bib/bbn011